Meow! It looks like this Hollywood relationship has hit a dead end. According to a hot new rumor, Gwyneth Paltrow is totally done with Madonna when it comes to their friendship (doesn’t it seem like it’s been years since the two have been photographed together, anyway?). Here’s what we’re reading from In Touch Magazine:

After more than a decade of friendship, Gwyneth Paltrow is taking a holiday from Madonna. “Everything always revolved around Madonna — and Gwyneth had enough,” says a source close to the Iron Man 3 star, 40. “She is finally done.” But the Material Girl, 54, isn’t losing sleep over the falling-out, says an insider: “Madonna’s schedule is insane. If Gwyneth doesn’t understand that, it’s her problem.” And Paltrow can always talk it out with Cameron Diaz.

Though the two have been close for years, Paltrow recently upgraded the actress, 40, to BFF status. “Gwyneth is a nurturer,” explains the source. “Cameron is bummed about being single, so Gwyneth sees her as a project. She’s trying to set her up with guys!”

Well, it’s good to see that Gwyneth has moved on with a new gal pal. Plus, with four kids and a world tour and everything else she’s been up to these days, it seems like Madonna just doesn’t have the time for girlie talk anymore. I could be wrong, but at least she has her boy toy to keep her busy!

Photos via FameFlynet